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  1. 重组蛋白
  2. Ubiquitin Related Proteins
  3. Ubiquitin/UBLs

Ubiquitin/UBLs  (泛素 & 泛素样蛋白)

Ubiquitin (Ub) is an evolutionarily conserved, heat-stable small protein containing 76 amino acids that is ubiquitously expressed in eukaryotic cells. It is highly conserved with little variance in animal species from insects to humans. Only 2-3 amino-acid residues vary between the yeast and plant and the yeast and human protein. Ubiquitin serves as a post-translational modifier of cellular substrates. Ubiquitin can be reversibly attached onto other proteins as a monomer or as a poly-ubiquitin chain of diverse structural topologies, and provides exceptionally flexible control over processes from cell division to cell death, from gene transcription to protein degradation, by dictating protein interaction, function, and turnover. Ubiquitin-like proteins (UBLs) encompass a family of proteins that share structural and evolutionary relationships with ubiquitin. The UBLs, including ubiquitin itself, share the same basic three-dimensional core structure, the β-grasp fold. Most UBLs are conjugated to proteins via an enzymatic cascade that resembles ubiquitylation, and many of their components are related to those involved in ubiquitylation. The UBLs family includes 10 members: small ubiquitin modifier (SUMO), neural precursor cell expressed developmentally downregulated 8 (NEDD8) or Related to Ubiquitin 1 (RUB 1) in yeast, Ubiquitin-Related Modifier-1 (URM1), Ubiquitin-fold Modifier 1 (UFM1), autophagy-related proteins 8 and 12 (ATG8 and ATG12), interferon-stimulated gene 15 (ISG15), human leukocyte antigen (HLA)-F adjacent transcript 10 (FAT10), fan ubiquitin-like protein 1 (FUB1), and histone mono-ubiquitination 1 (HUB1). Ubiquitin and UBLs are critical regulators of complex cellular processes such as the cell cycle, DNA repair, transcription, chromatin remodeling, signal translation, and protein degradation.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P70149
    ISG15/UCRP Protein, Human (His)

    rHuISG15/UCRP, His; Ubiquitin-Like Protein ISG15; Interferon-Induced 15 kDa Protein; Interferon-Induced 17 kDa Protein; IP17; Ubiquitin Cross-Reactive Protein; hUCRP; ISG15; G1P2; UCRP

    Human E. coli
  • HY-P71101
    UBB Protein, Human

    Polyubiquitin-B; UBB

    Human E. coli
    UBB 蛋白是一种中央调节因子,可在不同状态下形成共价连接的异肽键——单泛素、多泛素链或线性多泛素。多聚泛素链的功能随特定 Lys 残基的不同而变化:Lys-6 负责 DNA 修复,Lys-11 负责 ERAD 和细胞周期调节,Lys-29 负责蛋白毒性应激反应,Lys-33 负责激酶修饰,Lys-48 负责蛋白质降解,Lys-63 在内吞作用和 NF-kappa-B 激活中的作用。非锚定多聚泛素有助于多种作用,激活激酶和信号传导过程。UBB 还与 SKP1-KMD2A/B 复合物相互作用,强调其参与细胞途径和蛋白质相互作用。UBB Protein, Human 是重组的 UBB 蛋白,由 E. coli 表达,不带标签。UBB Protein, Human 全长 76 个氨基酸,分子量约为 ~7.0 kDa。
  • HY-P71681
    FAU Protein, Human (GST)

    FAU; Ubiquitin-like protein FUBI

    Human E. coli
    FAU 蛋白参与潜在的促凋亡活性,表明参与程序性细胞死亡途径。它在 40S 核糖体亚基中发挥作用,对于组装和功能至关重要。FAU 的双重性质,即调节细胞凋亡和促进核糖体组装,强调了其多方面的作用。其促凋亡活性的精确机制和对核糖体功能的影响是人们感兴趣的领域,揭示了更广泛的细胞功能。FAU Protein, Human (GST) 是重组的 FAU 蛋白,由 E. coli 表达,带有 N-GST 标签。FAU Protein, Human (GST) 全长 133 个氨基酸,分子量约为 ~41.4 kDa。
目录号 产品名 作用方式 纯度