韩国19禁爱情电影新高峰揭示

  1. 重组蛋白
  2. Viral Proteins
  3. SARS-CoV-2 Proteins

SARS-CoV-2 Proteins  (新冠病毒)

SARS-CoV is the coronavirus (CoV) that causes severe acute respiratory syndrome (SARS). CoVs are enveloped viruses with a positive-sense, single-stranded RNA and can cause health-threatening outbreaks by targeting human respiratory system, including not only SARS, but also Middle East respiratory syndrome (MERS) and SARS-CoV-2 (the cause of COVID-19). CoVs have four main structural proteins: spike(S), membrane (M), envelope (E), and nucleocapsid (N) proteins. An S protein mediates the CoV entry into host cells by attaching to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), followed by fusion between virus and host cell membranes. Genome replication and subgenomic RNA transcription after entry carry on with the participation of many nonstructural proteins such as Mpro (main protease or 3CLpro), PLpro (papain-like protease) and RdRp (RNA-dependent RNA polymerase). Then the structural proteins are translated, assembled into mature virions, and released via vesicles by exocytosis. It is worth mentioning that a protease called TMPRSS2 (transmembrane protease, serine 2) play important roles throughout the whole life of CoVs (such as attachment, assembling and release) by cleaving S protein. All the proteins and subcellular structures participated in the life cycle of CoVs are promising targets for treatment of disease caused by CoVs.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P73396
    SARS-CoV-2 S Protein RBD (HEK293)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
  • HY-P72035
    SARS-CoV-2 S glycoprotein (HEK293, His, Flag)

    E2 Peplomer protein

    Virus HEK293
    SARS-CoV-2 S 糖蛋白在感染中至关重要,它与 ACE2 受体结合,使病毒颗粒附着在宿主细胞膜上。S2/S2' 的裂解引发细胞膜融合或通过内吞作用内化。它还可能使用 NRP1/NRP2 和整合素作为替代受体,这可能解释嗅觉上皮细胞的向性。作为I类病毒融合蛋白,它在进入过程中经历不可逆的构象变化,具有三种状态:融合前天然、前发夹中间体和融合后发夹,涉及融合中的发夹三聚体结构。SARS-CoV-2 S glycoprotein (HEK293, His, Flag) 是重组的 SARS-CoV-2 S 糖蛋白,由 HEK293 表达,带有 N-10*His, C-Flag 标签。SARS-CoV-2 S glycoprotein (HEK293, His, Flag) 全长 670 个氨基酸,分子量约为 ~120 kDa。
  • HY-P72045
    SARS-CoV S Protein (HEK293, His-Myc)

    S glycoprotein; E2; Peplomer protein; Spike protein S1; Spike protein S2;

    Virus HEK293
    SARS-CoV S 蛋白通过与人类 ACE2 和 CLEC4M/DC-SIGNR 受体相互作用,将病毒颗粒附着到细胞膜上,从而协调病毒进入。它通过溶酶体降解下调宿主系链蛋白 (BST2),对抗其抗病毒活性。附着后,内化到宿主细胞内体中会诱导 S 糖蛋白构象变化,从而可能通过组织蛋白酶 CTSL 蛋白水解揭示 S2 的融合肽。这些过程凸显了 SARS-CoV S 蛋白在病毒进入和免疫逃避中的关键作用,强调了其在 SARS-CoV 发病机制中的重要性。进一步的研究对于理解潜在的分子机制和确定潜在的治疗靶点至关重要。SARS-CoV S Protein (HEK293, His-Myc) 是重组的 SARS-CoV S 蛋白,由 HEK293 表达,带有 N-10*His, C-Myc 标签。SARS-CoV S Protein (HEK293, His-Myc) 全长 222 个氨基酸,分子量约为 ~37 kDa。
  • HY-P72038
    SARS-CoV-2 S glycoprotein (HEK293, His-mFc)

    Spike glycoproteinRBD; ,Spike Protein RBD;

    Virus HEK293
    SARS-CoV-2 S 糖蛋白在感染中至关重要,它与 ACE2 受体结合,使病毒颗粒附着在宿主细胞膜上。S2/S2' 的裂解引发细胞膜融合或通过内吞作用内化。它还可能使用 NRP1/NRP2 和整合素作为替代受体,这可能解释嗅觉上皮细胞的向性。作为I类病毒融合蛋白,它在进入过程中经历不可逆的构象变化,具有三种状态:融合前天然、前发夹中间体和融合后发夹,涉及融合中的发夹三聚体结构。SARS-CoV-2 S glycoprotein (HEK293, His-mFc) 是重组的 SARS-CoV-2 S 糖蛋白,由 HEK293 表达,带有 C-mFc, C-6*His 标签。SARS-CoV-2 S glycoprotein (HEK293, His-mFc) 全长 223 个氨基酸,糖基化后的分子量为 ~66.0 kDa。
  • HY-P78283
    SARS-COV-2 S Protein RBD (HEK293, His-Avi)

    S protein RBD; S glycoprotein RBD; Spike protein RBD

    Virus HEK293
  • HY-P78106
    SARS-CoV-2 S Trimer Protein (Biotinylated, HEK293, His-Avi)

    S protein; Spike glycoprotein; S glycoprotein; COVID-19

    Virus HEK293
  • HY-P74447
    SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, His)

    SARS-CoV-2 RBD Protein; SARS-CoV-2 Spike RBD Protein; SARS-CoV-2 S Protein RBD

    Virus HEK293
  • HY-P74444
    SARS-CoV-2 S Protein (Omicron, B.1.1.529, His)

    SARS-CoV-2 Protein; SARS-CoV-2 Spike Protein

    Virus HEK293
  • HY-P74445
    SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, His)

    SARS-CoV-2 Protein; SARS-CoV-2 Spike Protein

    Virus HEK293
  • HY-P74445A
    SARS-CoV-2 S1 Protein (Omicron, B.1.1.529, C-His)

    SARS-CoV-2 Protein; SARS-CoV-2 Spike Protein

    Virus HEK293
  • HY-P78282
    SARS-COV-2 S Trimer Protein (HEK293, Fc)

    S protein; Spike glycoprotein; S glycoprotein; COVID-19

    Virus HEK293
  • HY-P72034
    SARS-CoV-2 Nucleocapsid Protein, Human (His)

    Nucleocapsid protein

    Human E. coli
    SARS-CoV-2 核衣壳蛋白在组装病毒体、形成螺旋核糖核衣壳 (RNP) 以及与病毒基因组和膜蛋白 M 相互作用方面发挥着至关重要的作用。除了其结构功能外,它还增强亚基因组病毒 RNA 转录和整体复制。它分泌于细胞外,与宿主趋化因子竞争 GAG 结合,可能破坏宿主防御机制并帮助病毒生命周期,强调其对 SARS-CoV-2 感染的多方面贡献。SARS-CoV-2 Nucleocapsid Protein, Human (His) 是重组的 SARS-CoV-2 核衣壳蛋白,由 E. coli 表达,带有 N-6*His 标签。SARS-CoV-2 Nucleocapsid Protein, Human (His) 全长 419 个氨基酸,分子量约为 ~48 kDa。
  • HY-P7436
    SARS-CoV-2 S1 Protein (HEK293)

    重组 S1 蛋白

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein (HEK293)是 HEK293 细胞产生的重组 S1 蛋白。
  • HY-P78275
    SARS-CoV-2 3CLpro/3C-like protease Protein

    3C-like protease; 3CL Protease; 3CL-Mpro; 3CL Pro; COVID-19; M Proteinase; Mpro

    Virus E. coli
  • HY-P7431
    SARS-CoV-2 S Protein RBD (194a.a, HEK293, His)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S Protein RBD (HEK293, His)是一种在 HEK293 细胞中产生的带 His 标签的重组 2019-nCov S 蛋白受体结合区域 (RBD)。
  • HY-P7431A
    SARS-CoV-2 S Protein RBD (194a.a, HEK293, C-His)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
  • HY-P7434
    SARS-CoV-2 S1 Protein (HEK293, mFc)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein (HEK293, mFc)是 HEK293 细胞产生的带 C-mFc 标签的重组 2019-nCoV S1 蛋白。
  • HY-P7435
    SARS-CoV-2 S1 Protein (HEK293, Fc)

    2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD

    Virus HEK293
    SARS-CoV-2 S1 Protein (HEK293, Fc)是 HEK293 细胞产生的带 C-Fc 标签的重组 2019-nCoV S1 蛋白。
  • HY-P74579
    SARS-CoV-2 RDRP Protein (sf9, His)

    SARS-CoV-2 (2019-nCoV) RNA-dependent RNA polymerase/RDRP Protein

    Virus Sf9 insect cells
  • HY-P70130
    SARS-CoV-2 NSP8 Protein (His)

    r2019-nCoV NSP8, His; SARS-CoV 2 nsp8

    Virus E. coli
    ORF1ab基因是SARS-CoV-2的特异性表达基因,可以快速、灵敏地检测以间接指示SARS-CoV-2的水平。ORF1ab 蛋白与病毒复制和转录、宿主翻译机制的抑制以及宿主免疫反应的抑制有关。SARS-CoV-2 NSP8 Protein (His) 是重组的 SARS-CoV-2 NSP8 蛋白,由 E. coli 表达,带有 C-6*His 标签。SARS-CoV-2 NSP8 Protein (His) 全长 198 个氨基酸,分子量约为 ~23.7 kDa。
目录号 产品名 作用方式 纯度