韩国19禁爱情电影新高峰揭示

  1. Academic Validation
  2. Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity

Bacteria-derived nanovesicles enhance tumour vaccination by trained immunity

  • Nat Nanotechnol. 2023 Dec 5. doi: 10.1038/s41565-023-01553-6.
Guangna Liu # 1 Nana Ma # 1 Keman Cheng # 1 Qingqing Feng 1 Xiaotu Ma 1 Yale Yue 1 Yao Li 1 Tianjiao Zhang 1 Xiaoyu Gao 1 Jie Liang 1 Lizhuo Zhang 1 Xinwei Wang 1 Zhenhua Ren 2 Yang-Xin Fu 2 3 Xiao Zhao 4 5 6 Guangjun Nie 7 8
Affiliations

Affiliations

  • 1 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.
  • 2 Changping Laboratory, Beijing, China.
  • 3 Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China.
  • 4 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China. zhaox@nanoctr.cn.
  • 5 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China. zhaox@nanoctr.cn.
  • 6 IGDB-NCNST Joint Research Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China. zhaox@nanoctr.cn.
  • 7 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China. niegj@nanoctr.cn.
  • 8 Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China. niegj@nanoctr.cn.
  • # Contributed equally.
Abstract

Trained immunity enhances the responsiveness of immune cells to subsequent infections or vaccinations. Here we demonstrate that pre-vaccination with bacteria-derived outer-membrane vesicles, which contain large amounts of pathogen-associated molecular patterns, can be used to potentiate, and enhance, tumour vaccination by trained immunity. Intraperitoneal administration of these outer-membrane vesicles to mice activates inflammasome signalling pathways and induces interleukin-1β secretion. The elevated interleukin-1β increases the generation of antigen-presenting cell progenitors. This results in increased immune response when tumour antigens are delivered, and increases tumour-antigen-specific T-cell activation. This trained immunity increased protection from tumour challenge in two distinct Cancer models.

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